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Irinotecan

 
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    IV
    Irinotecan
    Camptosar 

  • Mechanism of Action

  • Inhibits the activity of topoisomerase I, which is normally responsible for repairing DNA damage resulting from torsional strain.

Clinical Use

  • Indications

  • Certain solid organ organ malignancies, as guided by cancer specialists and local guidelines.
  • Adverse Effects
  • Neutropaenia
  • Anaemia
  • Dyspnoea
  • Nausea / vomiting
  • Cholinergic effects – lacrimation, sweating, diarrhoea
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