- Mechanism of Action
- Inhibits the activity of topoisomerase I, which is normally responsible for repairing DNA damage resulting from torsional strain.
Clinical Use
- Indication
- Certain solid organ organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Neutropaenia
- Anaemia
- Dyspnoea
- Nausea / vomiting
- Cholinergic effects – lacrimation, sweating, diarrhoea
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