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Irinotecan

  •  
    IV
    Irinotecan
    Camptosar 
    • Mechanism of Action
    • Inhibits the activity of topoisomerase I, which is normally responsible for repairing DNA damage resulting from torsional strain.

Clinical Use

    • Indication
    • Certain solid organ organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Neutropaenia
    • Anaemia
    • Dyspnoea
    • Nausea / vomiting
    • Cholinergic effects – lacrimation, sweating, diarrhoea
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