Irinotecan

• • Mechanism of Action

  • Inhibits the activity of topoisomerase I, which is normally responsible for repairing DNA damage resulting from torsional strain.

Clinical Use

• • Indications

  • Certain solid organ organ malignancies, as guided by cancer specialists and local guidelines.
• • Adverse Effects
  • Neutropaenia
  • Anaemia
  • Dyspnoea
  • Nausea / vomiting
  • Cholinergic effects – lacrimation, sweating, diarrhoea