Oral
Irbesartan
Avapro, Karvea
- Mechanism of Action
- Competitively inhibits the action of angiotensin II at AT1 receptors.
Clinical Use
- Indications
- Hypertension – first line management, especially in patients with chronic kidney disease (CKD)
- Heart failure
- Diabetic nephropathy
- Contraindications
- Severe renal impairment
- Severe hepatic impairment
- Patients on direct renin inhibitors (aliskiren)
- Adverse Effects
- Nausea / vomiting / diarrhoea
- Fatigue
- Oedema
- Upper respiratory tract infection
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