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Intravenous Immunoglobulin (IVIg)

  •  
    IV
    Intravenous Immunoglobulin (IVIg)
    Intragam, Octagam, Privigen, Flebogamma 
    • Mechanism of Action
    • For replacement - restores abnormally low IgG levels
      For immunomodulation - not fully understood, though believed to have multiple effects on T cells, B cells, cytokines, complement and Fc-receptors.

Clinical Use

    • Indications
    • Primary immunodeficiency disease
    • Symptomatic hypogammaglobulinaemia secondary to underlying disease or treatment
    • Idiopathic Thrombocytopaenic Purpura (ITP) in patients with high risk of bleeding or prior to surgery
    • Guillain Barré syndrome (GBS)
    • Kawasaki disease
    • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
    • Multifocal Motor Neuropathy (MMN)
    • Acute exacerbations of myaesthenia gravis (MG)
    • Lambert-Eaton Myasthenic Syndrome (LEMS)
    • Stiff person syndrome (SPS)
    • Adverse Effects
    • Infusion site reactions
    • Fevers
    • Headache
    • Lethargy
    • Nausea / vomiting
    • Arthralgias / myalgias
    • Aseptic meningitis

Potential Indications
BETA

Peripheral Nerve Disorders
Neuromuscular & Muscular

Associated Adverse Effects
BETA

CNS Infections
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