Intravenous Immunoglobulin (IVIg)
- IVIntravenous Immunoglobulin (IVIg)Intragam, Octagam, Privigen, Flebogamma
- Mechanism of Action
- For replacement - restores abnormally low IgG levels
- For immunomodulation - not fully understood, though believed to have multiple effects on T cells, B cells, cytokines, complement and Fc-receptors.
Clinical Use
- Indications
- Primary immunodeficiency disease
- Symptomatic hypogammaglobulinaemia secondary to underlying disease or treatment
- Idiopathic Thrombocytopaenic Purpura (ITP) in patients with high risk of bleeding or prior to surgery
- Guillain Barré syndrome (GBS)
- Kawasaki disease
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Multifocal Motor Neuropathy (MMN)
- Acute exacerbations of myaesthenia gravis (MG)
- Lambert-Eaton Myasthenic Syndrome (LEMS)
- Stiff person syndrome (SPS)
- Adverse Effects
- Infusion site reactions
- Fevers
- Headache
- Lethargy
- Nausea / vomiting
- Arthralgias / myalgias
- Aseptic meningitis