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Drug Guide

Intravenous Immunoglobulin (IVIg)

    Intravenous Immunoglobulin (IVIg)
    Intragam, Octagam, Privigen, Flebogamma 
  • Mechanism of Action
  • For replacement - restores abnormally low IgG levels
  • For immunomodulation - not fully understood, though believed to have multiple effects on T cells, B cells, cytokines, complement and Fc-receptors.

Clinical Use

  • Indications
  • Primary immunodeficiency disease
  • Symptomatic hypogammaglobulinaemia secondary to underlying disease or treatment
  • Idiopathic Thrombocytopaenic Purpura (ITP) in patients with high risk of bleeding or prior to surgery
  • Guillain Barré syndrome (GBS)
  • Kawasaki disease
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
  • Multifocal Motor Neuropathy (MMN)
  • Acute exacerbations of myaesthenia gravis (MG)
  • Lambert-Eaton Myasthenic Syndrome (LEMS)
  • Stiff person syndrome (SPS)
  • Adverse Effects
  • Infusion site reactions
  • Fevers
  • Headache
  • Lethargy
  • Nausea / vomiting
  • Arthralgias / myalgias
  • Aseptic meningitis
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