Insulin Glargine | Drug Guide - MedSchool
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Insulin Glargine

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    Subcut
    Insulin Glargine
    Lantus, Toujeo 
     
    Once daily dosing
    • Mechanism of Action
    • Insulin is an hormone normally produced by pancreatic beta cells that is responsible for regulation of glucose, fat and protein metabolism.
    • Pharmacology
    • Clear solution
    • Onset 1-3 hours
    • No peak
    • Duration <24 hours (Levemir) / >24 hours (Lantus)
    • Tend to suppress hepatic gluconeogenesis, preventing hyperglycaemia in fasting conditions
    • Prevent ketogenesis

Clinical Use

    • Indication
    • Basal insulin for hyperglycaemic control over 24 hours, either alone or in combination with bolus dosing.
    • Contraindications
    • Hypoglycaemia.
    • Adverse Effects
    • Hypoglycaemia
    • Weight gain
    • Hypersensitivity reactions
 
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