• Mechanism of Action
• Insulin is an hormone normally produced by pancreatic beta cells that is responsible for regulation of glucose, fat and protein metabolism.
• • Pharmacology
  • Clear solution
  • Onset 1-3 hours
  • No peak
  • Duration <24 hours (Levemir) / >24 hours (Lantus)
  • Tend to suppress hepatic gluconeogenesis, preventing hyperglycaemia in fasting conditions
  • Prevent ketogenesis

Clinical Use

• • Indication
  • Basal insulin for hyperglycaemic control over 24 hours, either alone or in combination with bolus dosing.
• • Contraindications
  • Hypoglycaemia.
• • Adverse Effects
  • Hypoglycaemia
  • Weight gain
  • Hypersensitivity reactions