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Infliximab

 
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  •  
    IV
    Infliximab
    Remicade 
     
    Chimaeric monoclonal antibody to TNF

  • Mechanism of Action

  • Inhibits tumour necrosis factor alpha (TNF-α), a cytokine involved in systemic inflammation and the acute phase response.

Clinical Use

  • Indications
  • Moderate to severe rheumatoid arthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Severe refractory ulcerative colitis
  • Severe refractory Crohn's disease
  • Psoriasis
  • Adverse Effects
  • Severe infections
  • Reactivation of tuberculosis
  • Anaemia
  • Headache
  • Nausea / diarrhoea
  • Exacerbation of congestive cardiac failure
  • Demyelinating disease
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