- Mechanism of Action
- Not completely known, though believed to have an effect at the distal convoluted tubule. Also thought to stimulate production of prostaglandin E2, resulting in vasodilation and decreased total peripheral resistance.
Clinical Use
- Indication
- First line therapy for hypertension, in combination with an ACEi or ARB.
- Adverse Effects
- Dizziness
- Headache
- Fatigue
- Muscle cramps
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