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Imatinib

  •  
    Oral
    Imatinib
    Glivec 
    • Mechanism of Action
    • Inhibits the Bcr-Abl tyrosine kinase as well as the stem cell receptor factor (cKIT) and several other receptor tyrosine kinases.

Clinical Use

    • Indications
    • First line treatment for chronic myeloid leukaemia
    • Philadelphia chromosome positive acute lymphoblastic leukaemia
    • Hypereosinophilic syndrome
    • cKIT positive unresectable or metastatic gastrointestinal stromal tumours
    • Adverse Effects
    • Rash
    • Fatigue
    • Oedema
    • Nausea / vomiting / diarrhoea
    • Muscle cramping
    • Peripheral neuropathy
    • LFT derangement
    • Myelosuppression - anaemia, neutropaenia, thrombocytopaenia

Potential Indications
BETA

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