×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

Ifosfamide

 
Bookmark
  •  
    IV
    Ifosfamide
    Ifex, Holoxan 
    • Mechanism of Action
    • A prodrug that is metabolized by the liver into phosphoramide mustard. This active metabolite shares nitrogen atoms between guanine residues in DNA, creating intrastrand and interstrand DNA crosslinks. Disruption of DNA results in cytotoxicity.

Clinical Use

    • Indication
    • Certain solid organ and haematologic malignancies, as guided by specialists and local guidelines
    • Adverse Effects
    • Monitoring
    • Regular monitoring of FBC and renal function.
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now