Oral / IV / Subcut
    Dilaudid (IR), Jurnista (SR) 
    Able to be used in renal dysfunction
    • Mechanism of Action
    • Act on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.
    • Pharmacology
    • Less histamine release (flushing, itching, rash) and less constipating than natural opioids.

Clinical Use

    • Indications
    • Acute and chronic pain
    • Opioid addiction (methadone / buprenorphine)
    • Adverse Effects
    • Nausea / vomiting
    • Constipation
    • Sedation
    • Respiratory depression
    • Diaphoresis
    • Delirium
    • Hypersensitivity – bronchospasm, urticaria
    • Bradycardia
    • Tolerance
    • Dependence
    • Hypogonadism
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