Oral / IV / Subcut
Hydromorphone
Dilaudid (IR), Jurnista (SR)
Able to be used in renal dysfunction
- Mechanism of Action
- Act on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.
- Pharmacology
- Less histamine release (flushing, itching, rash) and less constipating than natural opioids.
Clinical Use
- Indications
- Acute and chronic pain
- Opioid addiction (methadone / buprenorphine)
- Adverse Effects
- Nausea / vomiting
- Constipation
- Sedation
- Respiratory depression
- Diaphoresis
- Delirium
- Hypersensitivity – bronchospasm, urticaria
- Bradycardia
- Tolerance
- Dependence
- Hypogonadism
Want more info like this?
- Your electronic clinical medicine handbook
- Guides to help pass your exams
- Tools every medical student needs
- Quick diagrams to have the answers, fast
- Quizzes to test your knowledge
Explore