- Oral / IV / SubcutHydromorphoneDilaudid (IR), Jurnista (SR)Able to be used in renal dysfunction
- Mechanism of Action
- Act on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.
- Less histamine release (flushing, itching, rash) and less constipating than natural opioids.
- Adverse Effects