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Hydromorphone

 
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  •  
    Oral / IV / Subcut
    Hydromorphone
    Dilaudid (IR), Jurnista (SR) 
     
    Able to be used in renal dysfunction

  • Mechanism of Action

  • Act on opioid receptors (δ, κ and μ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.

  • Pharmacology

  • Less histamine release (flushing, itching, rash) and less constipating than natural opioids.

Clinical Use

  • Indications
  • Acute and chronic pain
  • Opioid addiction (methadone / buprenorphine)
  • Adverse Effects
  • Nausea / vomiting
  • Constipation
  • Sedation
  • Respiratory depression
  • Diaphoresis
  • Delirium
  • Hypersensitivity - bronchospasm, urticaria
  • Bradycardia
  • Tolerance
  • Dependence
  • Hypogonadism
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