Drug Guide
 

Hydrocortisone

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    IV / Topical
    Hydrocortisone
    Cortef 
    • Mechanism of Action
    • Suppresses the body’s normal inflammatory response through reduced monocyte recruitment, suppression of arachidonic acid metabolites - prostaglandin, leukotriene, platelet-activating factor and reduced production of interleukins, TNF-α, GM-CSF

Clinical Use

    • Indications
    • Acute asthma
    • Exacerbations of COPD
    • Croup
    • Other inflammatory conditions - dermatitides, ulcerative colitis, autoimmune haemolytic anaemia, acute gout, rheumatoid arthritis, seronegative arthritides, systemic lupus erythematosus, polyarteritis nodosa
    • Cerebral oedema
    • Nephrotic syndrome
    • Replacement therapy for adrenocortical insufficiency
    • Immunosuppression post organ transplant
    • Adverse Effects
    • Immunosuppression (risk of infection)
    • Osteoporosis
    • Steroid-induced diabetes mellitus
    • Cushing’s - central obesity, ‘moon’ face, buffalo hump, thin skin, peripheral oedema, striae, bruising
    • CNS - cognitive impairment / emotional instability / fatigue
    • Renal - sodium & water retention / hypertension / oedema
    • GIT - peptic ulceration, nausea / vomiting
    • Muscle wasting
    • Ocular - cataract / glaucoma
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