Hydrochlorothiazide

• Mechanism of Action
• Inhibits sodium-chloride transporters in the distal convoluted tubule, resulting in reduced sodium and chloride resorption.

Clinical Use

• • Indications
  • Essential hypertension – first line therapy, in combination with an ACEi or ARB
  • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
• • Adverse Effects
  • Hypersensitivity – urticarial, anaphylaxis
  • Dizziness
  • Anorexia
  • Hyperglycaemia
  • Hyperuricaemia