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Drug Guide
 
 

Hydrochlorothiazide

 
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 View Topic Outline
  •  
    Oral
    Hydrochlorothiazide
    Diathiazide 

  • Mechanism of Action

  • Inhibits sodium-chloride transporters in the distal convoluted tubule, resulting in reduced sodium and chloride resorption.

Clinical Use

  • Indications
  • Essential hypertension – first line therapy, in combination with an ACEi or ARB
  • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
  • Adverse Effects
  • Hypersensitivity – urticarial, anaphylaxis
  • Dizziness
  • Anorexia
  • Hyperglycaemia
  • Hyperuricaemia
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