Mechanism of Action
- Inhibits sodium-chloride transporters in the distal convoluted tubule, resulting in reduced sodium and chloride resorption.
- Essential hypertension – first line therapy, in combination with an ACEi or ARB
- Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
- Adverse Effects
- Hypersensitivity – urticarial, anaphylaxis