Mechanism of Action
- Inhibits sodium-chloride transporters in the distal convoluted tubule, resulting in reduced sodium and chloride resorption.
- Essential hypertension â€“ first line therapy, in combination with an ACEi or ARB
- Peripheral oedema â€“ due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
- Adverse Effects
- Hypersensitivity â€“ urticarial, anaphylaxis