Oral
Hydrochlorothiazide
Diathiazide
- Mechanism of Action
- Inhibits sodium-chloride transporters in the distal convoluted tubule, resulting in reduced sodium and chloride resorption.
Clinical Use
- Indications
- Essential hypertension – first line therapy, in combination with an ACEi or ARB
- Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
- Adverse Effects
- Hypersensitivity – urticarial, anaphylaxis
- Dizziness
- Anorexia
- Hyperglycaemia
- Hyperuricaemia
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