Hydrochlorothiazide Bookmark Share View Topic Outline Oral HydrochlorothiazideDiathiazide Mechanism of Action Inhibits sodium-chloride transporters in the distal convoluted tubule, resulting in reduced sodium and chloride resorption.Clinical UseIndicationsAdverse Effects Want more info like this? MedSchool Your electronic clinical medicine handbook Guides to help pass your exams Tools every medical student needs Quick diagrams to have the answers, fast Quizzes to test your knowledge Sign Up Now