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Haloperidol

 
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  •  
    Oral / IM / IV
    Haloperidol
    Haldol, Serenace 

  • Mechanism of Action

  • Inhibits dopamine D2 receptors, resulting in reduced dopaminergic transmission within the four dopaminergic pathways. Also inhibits serotonin (5-HT), muscarinic and α1-adrenergic receptors.

  • Pharmacology

  • More extrapyramidal side effects than atypical antipsychotics.

Clinical Use

  • Indications
  • Psychosis - schizophrenia, and related disorders
  • Acute mania
  • Tranquilization - in the acute psychiatric setting
  • Adverse Effects
  • Extrapyramidal - dystonia, akathisia, parkinsonism, tardive dyskinesia
  • Hyperprolactinaemia - gynaecomastia, galactorrhoea, infertility, sexual dysfunction
  • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention, delirium
  • Drowsiness
  • Postural hypotension
  • Prolonged QTc
  • Dyslipidaemia
  • Weight gain
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