• Mechanism of Action
• Inhibits dopamine D2 receptors, resulting in reduced dopaminergic transmission within the four dopaminergic pathways. Also inhibits serotonin (5-HT), muscarinic and α1-adrenergic receptors.
• • Pharmacology
  • More extrapyramidal side effects than atypical antipsychotics.

Clinical Use

• • Indications
  • Psychosis – schizophrenia, and related disorders
  • Acute mania
  • Tranquilization – in the acute psychiatric setting
• • Adverse Effects
  • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
  • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
  • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
  • Drowsiness
  • Postural hypotension
  • Prolonged QTc
  • Dyslipidaemia
  • Weight gain