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Glyceryl Trinitrate (GTN)

 
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    Oral / Subling / IV / Topical / Patch
    Glyceryl Trinitrate (GTN)
    Anginine tablet, Nitrolingual spray, Nitro-Dur Patch 
     
    Very short acting, to be used PRN when symptomatic
    • Mechanism of Action
    • Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
      Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)

Clinical Use

    • Indications
    • Adverse Effects
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