Glyceryl Trinitrate (GTN)
- Oral / Subling / IV / Topical / PatchGlyceryl Trinitrate (GTN)Anginine tablet, Nitrolingual spray, Nitro-Dur PatchVery short acting, to be used PRN when symptomatic
- Mechanism of Action
- Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)
- Adverse Effects