Drug Guide

Glyceryl Trinitrate (GTN)

    Oral / Subling / IV / Topical / Patch
    Glyceryl Trinitrate (GTN)
    Anginine tablet, Nitrolingual spray, Nitro-Dur Patch 
    Very short acting, to be used PRN when symptomatic
    • Mechanism of Action
    • Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
      Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)

Clinical Use

    • Indications
    • Stable angina pectoris
    • Acute chest pain
    • Oesophageal spasm
    • Acute hypertension (GTN infusion)
    • Heart failure (GTN infusion) – especially in the setting of hypertension or MI
    • Anal fissure (topical GTN)
    • Adverse Effects
    • Flushing
    • Headache / dizziness
    • Nausea / vomiting
    • Postural hypotension / tachycardia / syncope
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