Gliclazide
- OralGliclazideDiamicron
Mechanism of Action
- Inhibits potassium channels on pancreatic beta cell membranes, resulting in calcium influx and thus insulin release.
Clinical Use
Indications
- Glycaemic control for type II diabetes - second line
- Adverse Effects
- Hypoglycaemia
- Nausea / vomiting / diarrhea
- Thrombocytopaenia / leukopaenia / haemolytic anaemia
- Weight gain