×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

Gentamicin

 
Bookmark
  •  
    IV / IM
    Gentamicin

  • Mechanism of Action

  • Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
  • Microbiology

  • Active against Pseudomonas and most Enterobacteriaciae.

Clinical Use

  • Indications
  • Gram negative septicaemia
  • Directed therapy for severe and susceptible respiratory infections, UTI, skin infections, osteomyelitis or peritonitis
  • Adverse Effects
  • Nephrotoxicity – reversible, higher risk with poor renal function
  • Ototoxicity –  irreversible vestibular and auditory dysfunction
  • Peripheral neuropathy
  • Hypersensitivity reactions
  • Monitoring
  • To ensure therapeutic levels and prevent toxic levels:
  • Clinically – monitor for ataxia and hearing loss
  • Bloods – monitor serum gentamicin levels and creatinine / urea
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...