Drug Guide
 

Gentamicin

Bookmark
  •  
    IV / IM
    Gentamicin

    • Mechanism of Action
    • Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
    • Microbiology
    • Active against Pseudomonas and most Enterobacteriaciae.

Clinical Use

    • Indications
    • Gram negative septicaemia
    • Directed therapy for severe and susceptible respiratory infections, UTI, skin infections, osteomyelitis or peritonitis
    • Adverse Effects
    • Nephrotoxicity – reversible, higher risk with poor renal function
    • Ototoxicity –  irreversible vestibular and auditory dysfunction
    • Peripheral neuropathy
    • Hypersensitivity reactions
    • Monitoring
    • To ensure therapeutic levels and prevent toxic levels:
    • Clinically – monitor for ataxia and hearing loss
    • Bloods – monitor serum gentamicin levels and creatinine / urea
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Explore
   
 
Feedback