×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

Gemtuzumab-Ozogamicin

 
Bookmark
 View Topic Outline
  •  
    IV
    Gemtuzumab-Ozogamicin
    Mylotarg 
  • Mechanism of Action
  • Contains a monoclonal antibody directed toward CD-33 linked to a chemotherapeutic agent, allowing for targeted delivery of cytotoxic chemotherapy to CD33-positive cells.
  • The chemotherapeutic agent, N-acetyl gamma calicheamicin, is activated within targeted cells and induces double-standed DNA breaks.

Clinical Use

  • Indications

  • CD33 positive acute myeloid leukaemia.
  • Adverse Effects
  • Infusion reactions
  • Hepatotoxicity
  • Haemorrhage
  • Infections
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...