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Gemfibrozil

  •  
    Oral
    Gemfibrozil
    Lopid 
    • Mechanism of Action
    • Increases faecal excretion of cholesterol and inhibits hepatic triglyceride production.
    • Pharmacology
    • Reduce triglycerides by 25-50%
    • Reduce LDL by 5-20%
    • Increase HDL by 10-20%
    • Reduce incidence of coronary artery disease in type II diabetics

Clinical Use

    • Indications
    • Hypertriglyeridaemia (gemfibrozil)
    • Adjunctive treatment (along with statins) for elevated LDL (fenofibrate)
    • Secondary prevention of coronary artery / cerebrovascular / peripheral vascular disease / diabetes
    • Adverse Effects
    • Nausea / vomiting / diarrhea
    • Dyspepsia
    • Elevated LFTs

Potential Indications
BETA

Peripheral Vascular Disease
Ischaemic Stroke
Secondary Hyperlipidaemia
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