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Drug Guide


    Acneiform rash can be a major concern
  • Mechanism of Action
  • Inhibits epidermal growth factor receptor (EGFR), a transmembrane amino acid receptor tyrosine kinase found in approximately 15% of non small cell lung cancers.
  • EGFR mutations affect downstream signalling pathways resulting in cell proliferation
  • Inhibition of these receptors disrupts this proliferation pathway.

Clinical Use

  • Indications

  • Advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR mutation
  • Adverse Effects
  • Acneiform rash
  • Diarrhoea
  • Ocular changes
  • Alopecia
  • Nail changes
  • Interstitial lung disease
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