Fulvestrant

• Mechanism of Action
• Antagonises oestrogen receptors without agonist activity.

Clinical Use

• • Indication
  • Hormone receptor positive, locally advanced or metastatic breast cancer that does not respond to tamoxifen.
• • Adverse Effects
  • Elevated LFTs
  • Nausea / vomiting / diarrhoea
  • Hot flushes
  • Headache