Drug Guide


    IV / IM / Oral
    • Mechanism of Action
    • Inhibits the sodium-potassium-chloride cotransporters in the thick ascending limb of the loop of Henle, normally responsible for 25% of tubular sodium reabsorption. Inhibition results in increased excretion of sodium and, with it, water.

Clinical Use

    • Indications
    • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
    • Acute pulmonary oedema
    • Symptomatic ascites (second line treatment)
    • Hypertension– short-term therapy, in combination with ACEi / ARB
    • Adverse Effects
    • Hypokalaemia
    • Hyponatraemia
    • Dehydration / hypovolaemia
    • Hyperuricaemia
    • Muscle cramps
    • Headache
    • Hepatic encephalopathy in patients with liver disease
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