MedSchool: Ace Your OSCEsThe Medical Company
GET - On the App Store
Drug Guide


  • Mechanism of Action

  • Selectively inhibits the presynaptic serotonin (5-HT) transporter, resulting in reduced reuptake of serotonin and greater serotonin concentrations within the synapse.

Clinical Use

  • Indications
  • Depression
  • Obsessive-compulsive disorder
  • Generalised anxiety disorder
  • Contraindications

  • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
  • Adverse Effects
  • Insomnia
  • Drowsiness
  • Agitation
  • Dry mouth
  • Headache
  • Weight gain / loss
  • Nausea / vomiting / diarrhoea
  • Sexual dysfunction - decreased libido, ejaculatory disorders, erectile dysfunction
  • Serotonin syndrome (when SSRIs given with MAOis / SNRIs) - confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now

Snapshot: Initialising...