- Mechanism of Action
- Directly inhibits the binding of androgens to androgen receptors.
- Pharmacology
- Interacts only with androgen receptors, producing no progestin or glucocorticoid effects.
Clinical Use
- Indication
- Androgen deprivation therapy for metastatic castrate-resistant prostate cancer.
- Contraindications
- Seizure disorders.
- Adverse Effects
- Nausea / vomiting / diarrhoea
- Gynaecomastia / breast tenderness
- Hot flushes
- Dizziness
- Elevated LFTs
- Osteoporosis (long-term)
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