Fluoxetine | Drug Guide - MedSchool
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Fluoxetine

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  •  
    Oral
    Fluoxetine
    Prozac, Lovan 
    • Mechanism of Action
    • Selectively inhibits the presynaptic serotonin (5-HT) transporter, resulting in reduced reuptake of serotonin and greater serotonin concentrations within the synapse.

Clinical Use

    • Indications
    • Depression
    • Obsessive-compulsive disorder
    • Generalised anxiety disorder
    • Contraindications
    • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
    • Adverse Effects
    • Insomnia
    • Drowsiness
    • Agitation
    • Dry mouth
    • Headache
    • Weight gain / loss
    • Nausea / vomiting / diarrhoea
    • Sexual dysfunction – decreased libido, ejaculatory disorders, erectile dysfunction
    • Serotonin syndrome (when SSRIs given with MAOis / SNRIs) – confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
 
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