Fludrocortisone
- OralFludrocortisoneFlorinef
 
Mechanism of Action
- Binds to aldosterone receptors, resulting in sodium / water retention and potassium excretion through the kidneys, gut, salivary and sweat glands.
 
Clinical Use
- Indications
 - Adrenal insufficiency - Addison's, congenital adrenal hypoplasia
 - Orthostatic hypotension due to autonomic failure
 
- Adverse Effects
 - Sodium / fluid retention
 - Hypokalaemia
 - Muscle weakness
 - Osteoporosis
 - Peptic ulceration
 - Seizure
 - Cushing's - central obesity, 'moon' face, buffalo hump, thin skin, peripheral oedema, striae, bruising