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Fludrocortisone

  •  
    Oral
    Fludrocortisone
    Florinef 
    • Mechanism of Action
    • Binds to aldosterone receptors, resulting in sodium / water retention and potassium excretion through the kidneys, gut, salivary and sweat glands.

Clinical Use

    • Indications
    • Adrenal insufficiency – Addison’s, congenital adrenal hypoplasia
    • Orthostatic hypotension due to autonomic failure
    • Adverse Effects
    • Sodium / fluid retention
    • Hypokalaemia
    • Muscle weakness
    • Osteoporosis
    • Peptic ulceration
    • Seizure
    • Cushing’s - central obesity, ‘moon’ face, buffalo hump, thin skin, peripheral oedema, striae, bruising

Potential Indications
BETA

Orthostatic Hypotension
Adrenal Insufficiency
Congenital Adrenal Hyperplasia

Associated Adverse Effects
BETA

Cushing's Syndrome
Cushing's Syndrome
Gut
Osteoporosis
Osteoporosis
Nutritional Disorders
Electrolyte Abnormalities
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