Drug Guide
 

Fludrocortisone

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    Oral
    Fludrocortisone
    Florinef 
    • Mechanism of Action
    • Binds to aldosterone receptors, resulting in sodium / water retention and potassium excretion through the kidneys, gut, salivary and sweat glands.

Clinical Use

    • Indications
    • Adrenal insufficiency – Addison’s, congenital adrenal hypoplasia
    • Orthostatic hypotension due to autonomic failure
    • Adverse Effects
    • Sodium / fluid retention
    • Hypokalaemia
    • Muscle weakness
    • Osteoporosis
    • Peptic ulceration
    • Seizure
    • Cushing’s - central obesity, ‘moon’ face, buffalo hump, thin skin, peripheral oedema, striae, bruising
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