Oral / IV / IM / Subcut / Topical / Epidural
Fentanyl
Durogesic patch
Strong µ receptor selectivity
Short duration of action, though patches create a reservoir in the skin
- Mechanism of Action
- Acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.
Clinical Use
- Indication
- Acute and chronic pain
- Adverse Effects
- Nausea / vomiting
- Constipation
- Sedation
- Respiratory depression
- Diaphoresis
- Delirium
- Hypersensitivity – bronchospasm, urticaria
- Bradycardia
- Tolerance
- Dependence
- Hypogonadism
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