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Drug Guide
 
 

Fentanyl

 
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 View Topic Outline
  •  
    Oral / IV / IM / Subcut / Topical / Epidural
    Fentanyl
    Durogesic patch 
     
    Strong µ receptor selectivity
    Short duration of action, though patches create a reservoir in the skin

  • Mechanism of Action

  • Acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.

Clinical Use

  • Indications

  • Acute and chronic pain
  • Adverse Effects
  • Nausea / vomiting
  • Constipation
  • Sedation
  • Respiratory depression
  • Diaphoresis
  • Delirium
  • Hypersensitivity – bronchospasm, urticaria
  • Bradycardia
  • Tolerance
  • Dependence
  • Hypogonadism
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