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Fentanyl

  •  
    Oral / IV / IM / Subcut / Topical / Epidural
    Fentanyl
    Durogesic patch 
     
    Strong µ receptor selectivity
    Short duration of action, though patches create a reservoir in the skin
    • Mechanism of Action
    • Acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.

Clinical Use

    • Indication
    • Acute and chronic pain
    • Adverse Effects
    • Nausea / vomiting
    • Constipation
    • Sedation
    • Respiratory depression
    • Diaphoresis
    • Delirium
    • Hypersensitivity – bronchospasm, urticaria
    • Bradycardia
    • Tolerance
    • Dependence
    • Hypogonadism

Associated Adverse Effects
BETA

Opioid Dependence
Opioid Dependence
Delirium
Delirium
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