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Fenofibrate

 
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  •  
    Oral
    Fenofibrate
    Lipidil 

  • Mechanism of Action

  • Stimulates catabolism of lipoproteins, resulting in reduction of circulating triglyceride and cholesterol.
  • Pharmacology
  • Reduce triglycerides by 25-50%
  • Reduce LDL by 5-20%
  • Increase HDL by 10-20%
  • Reduce incidence of coronary artery disease in type II diabetics

Clinical Use

  • Indications
  • Hypertriglyeridaemia (gemfibrozil)
  • Adjunctive treatment (along with statins) for elevated LDL (fenofibrate)
  • Secondary prevention of coronary artery / cerebrovascular / peripheral vascular disease / diabetes
  • Adverse Effects
  • Nausea / vomiting / diarrhea
  • Dyspepsia
  • Elevated LFTs
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