- Mechanism of Action
- Stimulates catabolism of lipoproteins, resulting in reduction of circulating triglyceride and cholesterol.
- Pharmacology
- Reduce triglycerides by 25-50%
- Reduce LDL by 5-20%
- Increase HDL by 10-20%
- Reduce incidence of coronary artery disease in type II diabetics
Clinical Use
- Indications
- Hypertriglyeridaemia (gemfibrozil)
- Adjunctive treatment (along with statins) for elevated LDL (fenofibrate)
- Secondary prevention of coronary artery / cerebrovascular / peripheral vascular disease / diabetes
- Adverse Effects
- Nausea / vomiting / diarrhea
- Dyspepsia
- Elevated LFTs
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