Fenofibrate

• Mechanism of Action
• Stimulates catabolism of lipoproteins, resulting in reduction of circulating triglyceride and cholesterol.
• • Pharmacology
  • Reduce triglycerides by 25-50%
  • Reduce LDL by 5-20%
  • Increase HDL by 10-20%
  • Reduce incidence of coronary artery disease in type II diabetics

Clinical Use

• • Indications
  • Hypertriglyeridaemia (gemfibrozil)
  • Adjunctive treatment (along with statins) for elevated LDL (fenofibrate)
  • Secondary prevention of coronary artery / cerebrovascular / peripheral vascular disease / diabetes
• • Adverse Effects
  • Nausea / vomiting / diarrhea
  • Dyspepsia
  • Elevated LFTs