Subcut
Exenatide
Byetta (daily), Bydureon (weekly)
- Mechanism of Action
- Directly agonises GLP-1 receptors, resulting in glucose-dependant insulin secretion.
- Pharmacology
- Stimulates insulin secretion in hyperglycaemia, and Inhibits glucagon secretion in hyperglucagonaemia.
- Also results in delayed gastric emptying, appetite suppression and weight loss.
Clinical Use
- Indications
- Glycaemic control for type II diabetesGlycaemic control for type II diabetics
- Adjunctive therapy for weight loss
- Adverse Effects
- URTI
- Headache
- PancreatitisHypoglycaemia
- Headache
- Reflux
- Nausea / vomiting
- Pancreatitis
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