Drug Guide
 

Everolimus

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    Oral
    Everolimus
    Certican 
     
    Half-life ~30 hours
    • Mechanism of Action
    • Forms a complex with FKBP-12 to inhibit mTOR, a key regulatory protein, and induces cell cycle arrest of T cells, B cells and other non-immune cells.

Clinical Use

    • Indications
    • Prevention of graft rejection following kidney, liver or heart transplantation
    • Adverse Effects
    • Pancytopaenia
    • Infections (particularly respiratory and urinary tract)
    • Poor wound healing
    • Mouth ulcers
    • Male hypogonadism
    • Dyslipidaemia
    • Insomnia
    • Anxiety
    • Headache
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