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Drug Guide


    Half-life ~30 hours
  • Mechanism of Action

  • Forms a complex with FKBP-12 to inhibit mTOR, a key regulatory protein, and induces cell cycle arrest of T cells, B cells and other non-immune cells.

Clinical Use

  • Indications
  • Prevention of graft rejection following kidney, liver or heart transplantation
  • Adverse Effects
  • Pancytopaenia
  • Infections (particularly respiratory and urinary tract)
  • Poor wound healing
  • Mouth ulcers
  • Male hypogonadism
  • Dyslipidaemia
  • Insomnia
  • Anxiety
  • Headache
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