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Erlotinib

  •  
    Oral
    Erlotinib
    Tarceva 
     
    Acneiform rash can be a major concern
    • Mechanism of Action
    • Inhibits epidermal growth factor receptor (EGFR), a transmembrane amino acid receptor tyrosine kinase found in approximately 15% of non small cell lung cancers.
      EGFR mutations affect downstream signalling pathways resulting in cell proliferation
      Inhibition of these receptors disrupts this proliferation pathway.

Clinical Use

    • Indications
    • Advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR mutation
    • Locally advanced or metastatic non-small cell lung cancer after failure of primary chemotherapy
    • Locally advanced, unresectable or metastatic pancreatic cancer
    • Adverse Effects
    • Acneiform rash
    • Diarrhoea
    • Ocular changes
    • Alopecia
    • Nail changes
    • Interstitial lung disease

Potential Indications
BETA

Malignant Neoplasms
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