Epirubicin

• Mechanism of Action
• Inserted between DNA base pairs, resulting in inhibition of topoisomerase II.

Clinical Use

• • Indication
  • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
• • Adverse Effects
  • Bone marrow suppression – leucopaenia / anaemia / thrombocytopaenia
  • Cardiomyopathy / congestive cardiac failure
  • Nausea / vomiting / diarrhoea / anorexia
  • Stomatitis
  • Alopecia
  • Rash