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Eculizumab

  •  
    IV
    Eculizumab
    Soliris 
    • Mechanism of Action
    • A humanised monoclonal antibody directed against the terminal complement protein C5 that inhibits its cleavage into C5a and C5b, thus preventing formation of the membrane attack complex.

Clinical Use

    • Indications
    • Paroxysmal nocturnal haemoglobinuria
    • Atypical haemolytic uraemic syndrome (aHUS)
    • Adverse Effects
    • Headache
    • Fevers
    • Nausea / vomiting
    • Upper respiratory tract infection
    • Meningococcal infection

Potential Indications
BETA

Atypical Haemolytic Uraemic Syndrome
Paroxysmal Nocturnal Haemoglobinuria

Associated Adverse Effects
BETA

Meningococcal infection
Meningococcal infection
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