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Drug Guide
 
 

Eculizumab

 
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  •  
    IV
    Eculizumab
    Soliris 

  • Mechanism of Action

  • A humanised monoclonal antibody directed against the terminal complement protein C5 that inhibits its cleavage into C5a and C5b, thus preventing formation of the membrane attack complex.

Clinical Use

  • Indications
  • Paroxysmal nocturnal haemoglobinuria
  • Atypical haemolytic uraemic syndrome (aHUS)
  • Adverse Effects
  • Headache
  • Fevers
  • Nausea / vomiting
  • Upper respiratory tract infection
  • Meningococcal infection
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