Duloxetine | Drug Guide - MedSchool
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Duloxetine

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    Oral
    Duloxetine
    Cymbalta 
     
    Primarily inhibits noradrenaline reuptake
    • Mechanism of Action
    • Inhibits presynaptic reuptake of both serotonin and norepinephrine, resulting in greater concentrations within the synapse.

Clinical Use

    • Indications
    • Depression
    • Generalised anxiety disorder
    • Contraindications
    • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
    • Adverse Effects
    • Fatigue
    • Insomnia
    • Dry mouth
    • Weight loss / gain
    • Dizziness / headache
    • Nausea / vomiting / diarrhea
    • Sexual dysfunction – decreased libido, ejaculatory disorders, erectile dysfunction
    • Serotonin syndrome (when SNRIs given with MAOis / SSRIs) – confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
 
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