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Drug Guide
 
 

Duloxetine

 
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  •  
    Oral
    Duloxetine
    Cymbalta 
     
    Primarily inhibits noradrenaline reuptake

  • Mechanism of Action

  • Inhibits presynaptic reuptake of both serotonin and norepinephrine, resulting in greater concentrations within the synapse.

Clinical Use

  • Indications
  • Depression
  • Generalised anxiety disorder

  • Contraindications

  • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
  • Adverse Effects
  • Fatigue
  • Insomnia
  • Dry mouth
  • Weight loss / gain
  • Dizziness / headache
  • Nausea / vomiting / diarrhea
  • Sexual dysfunction - decreased libido, ejaculatory disorders, erectile dysfunction
  • Serotonin syndrome (when SNRIs given with MAOis / SSRIs) - confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
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