MedSchool: Ace Your OSCEsThe Medical Company
GET - On the App Store
Drug Guide


    IM / IV
    Used for acute episodes + nausea / vomiting
  • Mechanism of Action

  • Inhibits dopamine D2 receptors, resulting in reduced dopaminergic transmission within the four dopaminergic pathways. Also inhibits serotonin (5-HT), muscarinic and α1-adrenergic receptors.
  • Pharmacology

  • More extrapyramidal side effects than atypical antipsychotics.

Clinical Use

  • Indications
  • Tranquilization – in the acute psychiatric setting
  • Severe nausea / vomiting associated with surgery or anaesthesia
  • Status migrainosus
  • Adverse Effects
  • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
  • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
  • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
  • Drowsiness
  • Postural hypotension
  • Prolonged QTc
  • Dyslipidaemia
  • Weight gain
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now

Snapshot: Initialising...