Drug Guide


    IM / IV
    Used for acute episodes + nausea / vomiting
    • Mechanism of Action
    • Inhibits dopamine D2 receptors, resulting in reduced dopaminergic transmission within the four dopaminergic pathways. Also inhibits serotonin (5-HT), muscarinic and α1-adrenergic receptors.
    • Pharmacology
    • More extrapyramidal side effects than atypical antipsychotics.

Clinical Use

    • Indications
    • Tranquilization – in the acute psychiatric setting
    • Severe nausea / vomiting associated with surgery or anaesthesia
    • Status migrainosus
    • Adverse Effects
    • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
    • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
    • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
    • Drowsiness
    • Postural hypotension
    • Prolonged QTc
    • Dyslipidaemia
    • Weight gain
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge