Doxycycline
- OralDoxycycline
Mechanism of Action
- Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
Microbiology
- Broad range of activity against gram positives, gram negatives, atypical respiratory organisms (Legionella, Chlamydia, Mycoplasma), rickettsia and some spirochaetes
Clinical Use
- Indications
- Atypical pneumonia - Legionella, Chlamydophyla, Myoplasma
- Rickettsial infections - typhus, African tick bite fever, Rocky Mountain spotted fever, Australian tick typhus
- Malaria prophylaxis
- Lyme disease
- Brucellosis
- Chlamydia
- Syphilis
- Acne
- Adverse Effects
- Oesophagitis
- Photosensitivity
- Tooth discolouration
- Nausea / vomiting / diarrhoea
- Pseudomembranous colitis (C difficile)