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Drug Guide



  • Mechanism of Action

  • Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
  • Microbiology

  • Broad range of activity against gram positives, gram negatives, atypical respiratory organisms (Legionella, Chlamydia, Mycoplasma), rickettsia and some spirochaetes

Clinical Use

  • Indications
  • Atypical pneumonia - Legionella, Chlamydophyla, Myoplasma
  • Rickettsial infections - typhus, African tick bite fever, Rocky Mountain spotted fever, Australian tick typhus
  • Malaria prophylaxis
  • Lyme disease
  • Brucellosis
  • Chlamydia
  • Syphilis
  • Acne
  • Adverse Effects
  • Oesophagitis
  • Photosensitivity
  • Tooth discolouration
  • Nausea / vomiting / diarrhoea
  • Pseudomembranous colitis (C difficile)
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