Mechanism of Action
- Inserted between DNA base pairs, resulting in inhibition of topoisomerase II.
- Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Bone marrow suppression – leucopaenia / anaemia / thrombocytopaenia
- Cardiomyopathy / congestive cardiac failure
- Nausea / vomiting / diarrhoea / anorexia