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Doxorubicin

  •  
    IV
    Doxorubicin
    Adriamycin 
    • Mechanism of Action
    • Inserted between DNA base pairs, resulting in inhibition of topoisomerase II.

Clinical Use

    • Indication
    • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Bone marrow suppression – leucopaenia / anaemia / thrombocytopaenia
    • Cardiomyopathy / congestive cardiac failure
    • Nausea / vomiting / diarrhoea / anorexia
    • Stomatitis
    • Alopecia
    • Rash
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