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Doxepin

  •  
    Oral
    Doxepin
    Deptran 
    • Mechanism of Action
    • Blocks presynaptic reuptake of serotonin (5-HT) and noradrenaline (NA) through an unknown mechanism.

Clinical Use

    • Indications
    • Depression
    • Fibromyalgia
    • Migraine prophylaxis
    • Neuropathic pain
    • Post-traumatic stress disorder (PTSD)
    • Contraindications
    • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
    • Adverse Effects
    • Nausea / vomiting / diarrhea
    • Adrenergic – postural hypotension
    • Histaminic – sedation, weight gain
    • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention

Potential Indications
BETA

Fibromyalgia
Major Depressive Disorder
Posttraumatic Stress Disorder
Migraine
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