Mechanism of Action
- Blocks presynaptic reuptake of serotonin (5-HT) and noradrenaline (NA) through an unknown mechanism.
- Migraine prophylaxis
- Neuropathic pain
- Post-traumatic stress disorder (PTSD)
- Not for concurrent use with monoamine oxidase inhibitors (MAOi).
- Adverse Effects
- Nausea / vomiting / diarrhea
- Adrenergic – postural hypotension
- Histaminic – sedation, weight gain
- Anticholinergic - dry mouth, blurred vision, constipation, urinary retention