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Drug Guide
 
 

Doxepin

 
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    Oral
    Doxepin
    Deptran 
  • Mechanism of Action

  • Blocks presynaptic reuptake of serotonin (5-HT) and noradrenaline (NA) through an unknown mechanism.

Clinical Use

  • Indications
  • Depression
  • Fibromyalgia
  • Migraine prophylaxis
  • Neuropathic pain
  • Post-traumatic stress disorder (PTSD)
  • Contraindications

  • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
  • Adverse Effects
  • Nausea / vomiting / diarrhea
  • Adrenergic – postural hypotension
  • Histaminic – sedation, weight gain
  • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention
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