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Domperidone

 
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  •  
    Oral
    Domperidone
    Motilium 
     
    Binds D2 and D3 receptors; doesn't cross the BBB

  • Mechanism of Action

  • Antagonise CNS dopamine receptors, resulting in reduction in nausea and increased upper GI motility.

Clinical Use

  • Indications
  • Nausea / vomiting
  • Gastroparesis
  • Adverse Effects
  • Restlessness / anxiety / agitation
  • Fatigue
  • Headache / dizziness
  • Diarrhoea
  • Dystonic reactions (rare)
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