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Drug Guide


    Inhibits the cell cycle primarily in S phase
  • Mechanism of Action

  • Prevents cellular proliferation by binding to the beta unit of tubulin and inhibiting microtubule polymerization.

Clinical Use

  • Indications

  • Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
  • Adverse Effects
  • Bone marrow suppression - neutropaenia / anaemia / thrombocytopaenia
  • Oedema
  • Peripheral neuropathy
  • Nausea / vomiting / diarrhea
  • Elevated LFTs
  • Rash
  • Alopecia
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