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Drug Guide
 
 

Diltiazem

 
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  •  
    Oral
    Diltiazem
    Cardizem 
     
    Less cardio depression than with verapamil

  • Mechanism of Action

  • Inhibits L-type calcium channels on ventricular myocardial, cardiac nodal and arteriolar smooth muscle cells.

  • Pharmacology

  • Non-selectively inhibit calcium channels in the heart and arterioles, resulting in cardiac depression and vasodilation.

Clinical Use

  • Indications
  • Hypertension
  • Angina pectoris
  • Rate control of atrial fibrillation
  • Prophylaxis for paroxysmal supraventricular tachycardia (verapamil)
  • Prevention  of cluster headaches (verapamil)
  • Prophylaxis of migraine (verapamil)
  • Contraindications
  • AV block
  • Heart failure
  • Beta blockers – due to cardio depression
  • Adverse Effects
  • Constipation
  • Dizziness
  • Headache
  • Nausea
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