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Diltiazem

  •  
    Oral
    Diltiazem
    Cardizem 
     
    Less cardio depression than with verapamil
    • Mechanism of Action
    • Inhibits L-type calcium channels on ventricular myocardial, cardiac nodal and arteriolar smooth muscle cells.
    • Pharmacology
    • Non-selectively inhibit calcium channels in the heart and arterioles, resulting in cardiac depression and vasodilation.

Clinical Use

    • Indications
    • Hypertension
    • Angina pectoris
    • Rate control of atrial fibrillation
    • Prophylaxis for paroxysmal supraventricular tachycardia (verapamil)
    • Prevention  of cluster headaches (verapamil)
    • Prophylaxis of migraine (verapamil)
    • Contraindications
    • AV block
    • Heart failure
    • Beta blockers – due to cardio depression
    • Adverse Effects
    • Constipation
    • Dizziness
    • Headache
    • Nausea

Potential Indications
BETA

Atrial Fibrillation
Essential Hypertension
Migraine
Cluster Headache
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