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Drug Guide
 
 

Digoxin

 
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 View Topic Outline
  •  
    IV / Oral
    Digoxin
    Lanoxin 
  • Mechanism of Action
  • Inhibits Na⁺ / K⁺ ATPase, causing sodium influx which results in calcium influx through reduced action of the Na⁺ / Ca²⁺ exchange pump.
  • Increases contractility (positive inotropy) and decreases heart rate (negative chronotropy).

  • Pharmacology

  • Takes 5-7 days to achieve a therapeutic effect.

Clinical Use

  • Indications
  • Heart failure
  • Atrial fibrillation
  • Adverse Effects
  • Electrolyte abnormalities
  • Dizziness / headache
  • Blurred vision
  • Nausea / vomiting / diarrhea
  • Sinus bradycardia

  • Monitoring

  • Has a narrow therapeutic index, thus levels must be monitored regularly.
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