Drug Guide
 

Digoxin

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    IV / Oral
    Digoxin
    Lanoxin 
    • Mechanism of Action
    • Inhibits Na⁺ / K⁺ ATPase, causing sodium influx which results in calcium influx through reduced action of the Na⁺ / Ca²⁺ exchange pump.
      Increases contractility (positive inotropy) and decreases heart rate (negative chronotropy).
    • Pharmacology
    • Takes 5-7 days to achieve a therapeutic effect.

Clinical Use

    • Indications
    • Heart failure
    • Atrial fibrillation
    • Adverse Effects
    • Electrolyte abnormalities
    • Dizziness / headache
    • Blurred vision
    • Nausea / vomiting / diarrhea
    • Sinus bradycardia
    • Monitoring
    • Has a narrow therapeutic index, thus levels must be monitored regularly.
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