- IV / OralDigoxinLanoxin
- Mechanism of Action
- Inhibits Na⁺ / K⁺ ATPase, causing sodium influx which results in calcium influx through reduced action of the Na⁺ / Ca²⁺ exchange pump.
Increases contractility (positive inotropy) and decreases heart rate (negative chronotropy).
- Takes 5-7 days to achieve a therapeutic effect.
- Adverse Effects
- Has a narrow therapeutic index, thus levels must be monitored regularly.