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Drug Guide
 
 

Desvenlafaxine

 
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  •  
    Oral
    Desvenlafaxine
    Pristiq 
     
    Some additional inhibition of dopamine reuptake

  • Mechanism of Action

  • Inhibits presynaptic reuptake of both serotonin and norepinephrine, resulting in greater concentrations within the synapse.

Clinical Use

  • Indications

  • Depression

  • Contraindications

  • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
  • Adverse Effects
  • Fatigue
  • Insomnia
  • Dry mouth
  • Weight loss / gain
  • Dizziness / headache
  • Nausea / vomiting / diarrhea
  • Sexual dysfunction – decreased libido, ejaculatory disorders, erectile dysfunction
  • Serotonin syndrome (when SNRIs given with MAOis / SSRIs) – confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
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