Oral
Desvenlafaxine
Pristiq
Some additional inhibition of dopamine reuptake
- Mechanism of Action
- Inhibits presynaptic reuptake of both serotonin and norepinephrine, resulting in greater concentrations within the synapse.
Clinical Use
- Contraindications
- Not for concurrent use with monoamine oxidase inhibitors (MAOi).
- Adverse Effects
- Fatigue
- Insomnia
- Dry mouth
- Weight loss / gain
- Dizziness / headache
- Nausea / vomiting / diarrhea
- Sexual dysfunction – decreased libido, ejaculatory disorders, erectile dysfunction
- Serotonin syndrome (when SNRIs given with MAOis / SSRIs) – confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
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