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Desflurane

 
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  •  
    Inhaled
    Desflurane
    Airway irritant - causes cough, apnoea, laryngospasm

  • Mechanism of Action

  • Not clearly defined. Alters the configuration of cell membrane ion channels, reducing the rate of firing of action potentials and resulting in CNS depression.

Clinical Use

  • Indications

  • Induction and maintenance of general anaesthesia.
  • Contraindications
  • Past unexplained jaundice or malignant hyperthermia following halothane administration
  • Raised intracranial pressure
  • Adverse Effects
  • Hypotension
  • Bradycardia (halothane / sevoflurane)
  • Tachycardia (desflurane / isoflurane)
  • Cardiac arrhythmia
  • Reduced tidal volume with increased respiratory rate
  • Reduced renal blood flow and glomerular filtration rate
  • Hepatotoxicity
  • Malignant hyperthermia
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