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Drug Guide

 

 

 

 

Denosumab

 
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  •  
    Subcut
    Denosumab
    Prolia, Xgeva 
     
    Six-monthly injections

  • Mechanism of Action

  • An IgG monoclonal antibody that binds to and inhibits RANK ligand, a cytokine normally responsible for stimulation of osteoclastic maturation and function.

Clinical Use

  • Indications
  • Osteoporosis.
  • Bone metastases
  • Hypercalcaemia of malignancy (refractory to bisphosphonates)
  • Adverse Effects
  • Back pain / myalgia / arthralgia
  • Hypertension
  • Dyslipidaemia
  • Rash
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