Drug Guide
 

Denosumab

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    Subcut
    Denosumab
    Prolia, Xgeva 
     
    Six-monthly injections
    • Mechanism of Action
    • An IgG monoclonal antibody that binds to and inhibits RANK ligand, a cytokine normally responsible for stimulation of osteoclastic maturation and function.

Clinical Use

    • Indications
    • Osteoporosis.
    • Bone metastases
    • Hypercalcaemia of malignancy (refractory to bisphosphonates)
    • Adverse Effects
    • Back pain / myalgia / arthralgia
    • Hypertension
    • Dyslipidaemia
    • Rash
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