- SubcutDenosumabProlia, XgevaSix-monthly injections
Mechanism of Action
- An IgG monoclonal antibody that binds to and inhibits RANK ligand, a cytokine normally responsible for stimulation of osteoclastic maturation and function.
- Bone metastases
- Hypercalcaemia of malignancy (refractory to bisphosphonates)
- Adverse Effects
- Back pain / myalgia / arthralgia