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Dasatinib

  •  
    Oral
    Dasatinib
    Sprycel 
     
    Binds both active & inactive conformation of Bcr-Abl kinase, resulting in reduced resistance
    • Mechanism of Action
    • Inhibits the Bcr-Abl tyrosine kinase as well as the stem cell receptor factor (cKIT) and several other receptor tyrosine kinases.

Clinical Use

    • Indications
    • Philadelphia chromosome positive chronic myeloid leukaemia in the chronic phase or with resistance or intolerance to imatinib
    • Philadelphia chromosome positive acute lymphoblastic leukaemia
    • Adverse Effects
    • Rash
    • Fatigue
    • Oedema
    • Nausea / vomiting / diarrhoea
    • Muscle cramping
    • Peripheral neuropathy
    • LFT derangement
    • Myelosuppression - anaemia, neutropaenia, thrombocytopaenia
    • Respiratory - pleural effusions, pulmonary hypertension

Potential Indications
BETA

Chronic Myeloid Leukaemia
Acute Lymphoblastic Leukaemia
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