Dacarbazine

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    Dacarbazine

    • Mechanism of Action
    • Creates DNA adducts that cause base-base mismatches and DNA instability.

Clinical Use

    • Indication
    • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
    • Nausea / vomiting / diarrhoea
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