- Mechanism of Action
- Creates DNA adducts that cause base-base mismatches and DNA instability.
Clinical Use
- Indication
- Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
- Nausea / vomiting / diarrhoea
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