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Drug Guide
 
 

Dabigatran

 
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  •  
    Oral
    Dabigatran
    Pradaxa 

  • Mechanism of Action

  • Reversibly inhibits factor IIa (thrombin), resulting in reduced fibrin clot formation.

  • Pharmacology

  • Idarucizumab (praxbind) may be used to reverse dabigatran in life-threatening situations only.

Clinical Use

  • Indications
  • Prevention of venous thromboembolism post hip / knee surgery
  • Treatment of venous thromboembolism (DVT / PE)
  • Non-valvular atrial fibrillation (prevention of stroke)
  • Contraindications
  • Active bleeding or risk of major bleeding
  • Use of other anticoagulants
  • Mechanical heart valve
  • Severe renal impairment (eGFR
  • Adverse Effects
  • Haemorrhage
  • Oesophageal ulceration

  • Monitoring

  • A dilute thrombin time assay may be used to monitor dabigatran.
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