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Dabigatran

  •  
    Oral
    Dabigatran
    Pradaxa 
    • Mechanism of Action
    • Reversibly inhibits factor IIa (thrombin), resulting in reduced fibrin clot formation.
    • Pharmacology
    • Idarucizumab (praxbind) may be used to reverse dabigatran in life-threatening situations only.

Clinical Use

    • Indications
    • Prevention of venous thromboembolism post hip / knee surgery
    • Treatment of venous thromboembolism (DVT / PE)
    • Non-valvular atrial fibrillation (prevention of stroke)
    • Contraindications
    • Active bleeding or risk of major bleeding
    • Use of other anticoagulants
    • Mechanical heart valve
    • Severe renal impairment (eGFR <30mL/min)
    • Severe hepatic disease with coagulopathy
    • Concurrent use of azole antimycotics
    • Adverse Effects
    • Haemorrhage
    • Oesophageal ulceration
    • Monitoring
    • A dilute thrombin time assay may be used to monitor dabigatran.

Potential Indications
BETA

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