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Cytarabine / Cytosine Arabinoside

 
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    IV
    Cytarabine / Cytosine Arabinoside

  • Mechanism of Action

  • Incorporated into DNA, resulting in disruption of DNA synthesis through inhibition of DNA polymerase activity.

Clinical Use

  • Indications

  • Certain haematologic organ malignancies, as guided by cancer specialists and local guidelines.
  • Adverse Effects
  • Bone marrow suppression - anaemia / leukopaenia / thrombocytopaenia
  • Nausea / vomiting / diarrhoea / anorexia
  • Stomatitis / mouth ulcers
  • Elevated LFTs
  • Alopecia
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