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Cyclosporin

  •  
    Oral / IV
    Cyclosporin
    Sandimmun, Neoral 
    • Mechanism of Action
    • Inhibits T cell activation as well as transcription of IL-2 and other cytokines, through inhibition of calcineurin-mediated activation of NFAT.

Clinical Use

    • Indications
    • Prevention of graft rejection following kidney, liver or heart transplantation
    • Nephrotic syndrome refractory to other medications
    • Severe rheumatoid arthritis refractory to other medications
    • Severe psoriasis refractory to other medications
    • Severe atopic dermatitis refractory to other medications
    • Adverse Effects
    • Increased risk of infection (immunosuppression)
    • Fluid overload
    • Hypertension
    • Fevers
    • Hirsutism
    • LFT derangement
    • Renal impairment
    • Dyslipidaemia
    • Monitoring
    • Baseline and regular electrolytes, renal function, LFTs, FBC and lipids.

Potential Indications
BETA

Associated Adverse Effects
BETA

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