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Drug Guide
 
 

Cyclophosphamide

 
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    Oral / IV
    Cyclophosphamide
    Cyclonex, Endoxan 
    • Mechanism of Action
    • A prodrug that is metabolized by the liver into phosphoramide mustard. This active metabolite shares nitrogen atoms between guanine residues in DNA, creating intrastrand and interstrand DNA crosslinks. Disruption of DNA results in cytotoxicity.

Clinical Use

    • Indications
    • Adverse Effects
    • Monitoring
    • Regular monitoring of FBC and renal function.
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