- Oral / IVCyclophosphamideCyclonex, Endoxan
- Mechanism of Action
- A prodrug that is metabolized by the liver into phosphoramide mustard. This active metabolite shares nitrogen atoms between guanine residues in DNA, creating intrastrand and interstrand DNA crosslinks. Disruption of DNA results in cytotoxicity.
- Adverse Effects
- Regular monitoring of FBC and renal function.