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Crizotinib

 
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  •  
    Oral
    Crizotinib
    Xalkori 

  • Mechanism of Action

  • Anaplastic lymphoma kinase (ALK) is a novel receptor tyrosine kinase associated with ~60% of anaplastic large-cell lymphoma and ~5% of non-small cell lung cancer. Inhibition of these receptors interrupts downstream signalling pathways and suppresses cellular proliferation.

Clinical Use

  • Indications

  • ALK-positive locally advanced or metastatic non small cell lung cancer (NSCLC).
  • Adverse Effects
  • Visual phenomena
  • Nausea / vomiting / diarrhoea
  • Neutropaenia
  • Pneumonitis
  • LFT derangement
  • Bradycardia
  • Oedema
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